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REDLARA: Comparison of stimulation with clomiphene citrate in combination with recombinant follicle-stimulating hormone and recombinant luteinizant hormone to stimulation with a gonadotropin-releasing hormone agonist protocol: a prospective, randomized study.

Monika Weigert, m.D., Ursula Krischker, M.D., Michaela Pöhl, M.D., Gunda Poschalko, M.D., Christoph Kindermann, M.D., and Wilfried Feichtinger, M.D.
 
Fertil Steril Vol. 78 (1): 34-39 (july 2002)
 
Abstract
 
Objetive: To compare IVF-ET outcome with a new stimulation protocol using clomiphene citrate (CC) with recombinant FSH and LH to stimulation with the standard long GnRH-a protocol.
 
Design: Prospective randomized study.
 
Setting: Outpatient infertility clinic in Vienne, Austria.
 
Patient(s): Two hundred ninety-four infertile women undergoing IVF-ET; 154 IVF cycles stimulated with CC + recombinant FSH + recombinant LH (group A) and 140 cycles with long GnRH-a suppresion + recombinant FSH (group B).
 
Intervention(s): Controlled ovarian hyperstimulation, egg retrieval, and ET.
 
Main Outcome Measure(s): Cycle parameters (number of oocytes, fertilization, number of embryos) and outcome (pregnancy rate, cancellation rate, ovarian hyperstimulation syndrome [OHSS]).
 
Result(s): Pregnancy rate per ET was 42.9% (implation rate, 21.3%) in group A and 12 cases (10%) in group B.
 
Conclusion(s): Stimulation with CC + recombinant FSH + recombinant LH leads to comparable pregnancy rates vs. the long protocol. With this new stimulation, less gonadotropins are used and there is less need for monitoring (lower cost for patient and clinic). The risk of OHSS is reduced as well. Therefore, this protocol should be regarded as the first-line treatment.
 
Key Words: CC, long protocol, GnRH-a down-regulation, IVF-ET, pregnancy rate, OHSS. 

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