"We invite all centres of REDLARA and new centres performing Assisted Reproduction procedures to report their data corresponding to the year 2015.
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One hundred and thirty centers from twelve countries reported results of assisted reproductive techniques (ART) from treatments initiated during 2006.
During this period a total of 29,763 ART procedures, including perinatal results, were reported; 22,279 initiated cycles following IVF/ICSI/GIFT; 3,982 embryo transfers using donated oocytes (OD); and 3,052 transfers using frozen/thawed embryos (FTE). This represents an 8.5% increase in comparison to the procedures performed in 2005.
In our region, the age of the female partner undergoing ART procedures continues to increase : in 2006, 54.0% of FIV/ICSI embryo transfers were performed in women aged ≥ 35 years; without a decrease in the number of embryos transferred. The transfer of ≥3 embryos represents more than half of embryo transfers, regardless of the age of the woman or ART procedure.
The main prognosis factor for success in IVF/ICSI cycles are the age of the female partner and the number of embryos transferred. The transfer of >2 embryos did not improve the pregnancy rate significantly but instead, increased the rate of multiple pregnancy, especially that of triplets or more. In OD cycles, the number of embryos transferred showed the same effect as in cases of IVF/ICSI with autologus oocytes. Moreover, the age of the oocyte receptor did not affect the pregnancy rate.
A total of 8,262 clinical pregnancies were reported, 19.1% resulted in a miscarriage. This frequency was significantly higher in FTE (both autologous and OD) than in fresh embryo-transfers (both autologous and OD).
The live birth delivery rate per transfer was 25.2% in cycles with IVF/ICSI; 34.1% in cycles with fresh embryo transfers using OD and 13.3% in cycles with FTE transfers.
A total of 8,462 babies were reported, 56.6% were singleton, 33.9% were double, and 9.5% =triplet. The prematurity rate was 16.3% in singletons, 59.2% in doubles, and 90.2% in ≥triplets.
The elective transfer of one and two embryos represented 6.5% and 33.7% of one embryo-transfers and two-embryos-transfers, respectively. This proportion was higher in women aged ≥34 years.
A total of 319 transfers of embryos subjected to preimplantational genetic diagnosis were reported. 47.9% of the embryos studied were reported as normal, and on average 1.7 embryos were transferred. 32.0% of transfers were in women aged ≥34 years, 37.9% in women aged 35 through 39 years, and 30.1% in women aged ≥40 years. The delivery rate per transfer was 30.4%, 19.8% and 18.8% respectively.